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Grape seed extract prolongs mice's lifespan.
Procyanidin C1 (PCC1), a polyphenolic component of grape seed extract, affects senescent cells.
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One of the nine hallmarks of aging - cellular senescence, is a cellular state that involves several changes culminating in the overproduction of inflammatory cytokines. This signaling molecule is secreted by immune cells and upregulates the inflammatory reaction. Its excessive production leads to inflammatory diseases linked to other conditions, such as cancer or atherosclerosis.
The accumulation of senescent cells determines the senescence-associated secretory phenotype (SASP), which is the main cause of the damaging effects of senescent cells. As studies in rodent models have shown, the good news is that the process of cellular senescence can be prevented or delayed with medication.
Low concentrations of Procyanidin C1 (PCC1), a polyphenolic component of grape seed extract, prevent SASP formation. Higher concentrations of PCC1 destroy senescent cells. PCC1 decreases the number of senescent cells in tumors and improves the efficacy of chemotherapy treatment on mice. In old mice, the compound prolongs survival and mitigates age-related decay.
The authors of the study believe that PCC1, as a natural aging treatment factor, has excellent clinical application potential in delaying or preventing age-related diseases.
Source: nature.com
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One of the nine hallmarks of aging - cellular senescence, is a cellular state that involves several changes culminating in the overproduction of inflammatory cytokines. This signaling molecule is secreted by immune cells and upregulates the inflammatory reaction. Its excessive production leads to inflammatory diseases linked to other conditions, such as cancer or atherosclerosis.
The accumulation of senescent cells determines the senescence-associated secretory phenotype (SASP), which is the main cause of the damaging effects of senescent cells. As studies in rodent models have shown, the good news is that the process of cellular senescence can be prevented or delayed with medication.
Low concentrations of Procyanidin C1 (PCC1), a polyphenolic component of grape seed extract, prevent SASP formation. Higher concentrations of PCC1 destroy senescent cells. PCC1 decreases the number of senescent cells in tumors and improves the efficacy of chemotherapy treatment on mice. In old mice, the compound prolongs survival and mitigates age-related decay.
The authors of the study believe that PCC1, as a natural aging treatment factor, has excellent clinical application potential in delaying or preventing age-related diseases.
Source: nature.com
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
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Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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