Longevity Conferences 2023
January 19, 2023
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A single nucleotide polymorphism (SNP) of the mitochondrial transcription factor A (TFAM) rs1937 is associated with longevity
The research on 3294 Chinese elders showed a positive association between rs1937 SNP and longevity.
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Mitochondria are organelles involved in cellular senescence and organismal aging containing mitochondrial DNA (mtDNA). They are a source and target of reactive oxygen species (ROS) and the main adenosine triphosphate (ATP) production sites. The ROS can cause oxidative damage to mtDNA contained in mitochondria, inducing mtDNA mutations and, consequently, aging. Among others, chronic mtDNA dysfunction and damage are the main features of neurodegenerative diseases and the aging process.Mitochondrial transcription factor A (TFAM) is a protein essential for mtDNA initiation, transcription, and replication regulation
Data from saliva samples of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) study was used to conduct a case-control study examining the association of SNP rs1937 with longevity. The research included 3294 Chinese elders divided into two groups according to age. This article showed a positive association between rs1937 SNP and longevity. In comparison to the younger elderly group (age 65-74), the long-lived individual's group (≥90 years) having "CC genotype" of rs1937 SNP were more closely linked to prolonged longevity than those with "GG genotype. Thus, this SNP may be a potential biomarker for a longer human life span
Single nucleotide polymorphisms (SNPs) are a type of genetic variation among people and are based on single nucleotide differences such as cytosine (C) to guanine (G) substitution.. Increased levels of TFAM can reverse neuron damage, while SNP of rs1937 on TFAM were associated with Alzheimer's disease (AD). The C allele of rs1937 appears to be protective against late-onset Alzheimer's disease in Han Chinese. Deficiency in TFAM protein could induce multimorbidity and premature senescence.
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Source: https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-021-02655-3
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Mitochondria are organelles involved in cellular senescence and organismal aging containing mitochondrial DNA (mtDNA). They are a source and target of reactive oxygen species (ROS) and the main adenosine triphosphate (ATP) production sites. The ROS can cause oxidative damage to mtDNA contained in mitochondria, inducing mtDNA mutations and, consequently, aging. Among others, chronic mtDNA dysfunction and damage are the main features of neurodegenerative diseases and the aging process.Mitochondrial transcription factor A (TFAM) is a protein essential for mtDNA initiation, transcription, and replication regulation
Data from saliva samples of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) study was used to conduct a case-control study examining the association of SNP rs1937 with longevity. The research included 3294 Chinese elders divided into two groups according to age. This article showed a positive association between rs1937 SNP and longevity. In comparison to the younger elderly group (age 65-74), the long-lived individual's group (≥90 years) having "CC genotype" of rs1937 SNP were more closely linked to prolonged longevity than those with "GG genotype. Thus, this SNP may be a potential biomarker for a longer human life span
Single nucleotide polymorphisms (SNPs) are a type of genetic variation among people and are based on single nucleotide differences such as cytosine (C) to guanine (G) substitution.. Increased levels of TFAM can reverse neuron damage, while SNP of rs1937 on TFAM were associated with Alzheimer's disease (AD). The C allele of rs1937 appears to be protective against late-onset Alzheimer's disease in Han Chinese. Deficiency in TFAM protein could induce multimorbidity and premature senescence.
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Source: https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-021-02655-3
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
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Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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