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Daily multivitamin-mineral supplementation protects the brain
Deficiencies in micronutrients (vitamins and minerals) increase the risk of cognitive decline and dementia.
Unprocessed cocoa contains large amounts of catechins and epicatechins, compounds belonging to flavanols (a subclass of flavonoids), and modest amounts of caffeine and theobromine (an alkaloid). Research indicates that consuming flavanols improves cerebral vasodilation, blood flow, and angiogenesis which could slow cognitive decline. The bulk of evidence supporting the cognitive-enhancing capacity of flavonoids comes from a few clinical studies and epidemiological trials on healthy older adults.
Deficiencies in micronutrients (vitamins and minerals) increase the risk of cognitive decline and dementia because they play a role in various biologic pathways that support brain and body functions. Evidence from the literature regarding the impact of vitamin D, omega-3, B vitamins, and other micronutrients on cognitive function has yielded mixed results. The outcome variation is possibly attributed to the tests administered, outcomes measured, subjects’ demographics, and nutritional status.
Studies spanning more than 12 months investigating the potential of multivitamin-mineral (MVM) alone or in combination to enhance cognitive function in older adults (≥65 years) are limited, with only a single randomized controlled trial being available. Baker et al. sought to cover this gap by studying the 3-year effects of daily treatment with cocoa extract and/or a MVM (Centrum Silver, Pfizer) on cognitive function in older adults. The study population consisted of 2262 participants.
The study revealed that daily cocoa extract did not affect global cognitive function. Furthermore, it showed that daily MVM supplementation resulted in a significant benefit to global cognition compared to placebo, especially in the group with cardiovascular diseases. Also, the analysis revealed that MVM supported memory and executive function.
The authors concluded that the use of a MVM supplement could potentially improve or protect cognitive function in older adults. This represents a safe, accessible, low-cost option that is readily available to achieve the feat. Additional research is needed to confirm the findings of this trial.
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Unprocessed cocoa contains large amounts of catechins and epicatechins, compounds belonging to flavanols (a subclass of flavonoids), and modest amounts of caffeine and theobromine (an alkaloid). Research indicates that consuming flavanols improves cerebral vasodilation, blood flow, and angiogenesis which could slow cognitive decline. The bulk of evidence supporting the cognitive-enhancing capacity of flavonoids comes from a few clinical studies and epidemiological trials on healthy older adults.
Deficiencies in micronutrients (vitamins and minerals) increase the risk of cognitive decline and dementia because they play a role in various biologic pathways that support brain and body functions. Evidence from the literature regarding the impact of vitamin D, omega-3, B vitamins, and other micronutrients on cognitive function has yielded mixed results. The outcome variation is possibly attributed to the tests administered, outcomes measured, subjects’ demographics, and nutritional status.
Studies spanning more than 12 months investigating the potential of multivitamin-mineral (MVM) alone or in combination to enhance cognitive function in older adults (≥65 years) are limited, with only a single randomized controlled trial being available. Baker et al. sought to cover this gap by studying the 3-year effects of daily treatment with cocoa extract and/or a MVM (Centrum Silver, Pfizer) on cognitive function in older adults. The study population consisted of 2262 participants.
The study revealed that daily cocoa extract did not affect global cognitive function. Furthermore, it showed that daily MVM supplementation resulted in a significant benefit to global cognition compared to placebo, especially in the group with cardiovascular diseases. Also, the analysis revealed that MVM supported memory and executive function.
The authors concluded that the use of a MVM supplement could potentially improve or protect cognitive function in older adults. This represents a safe, accessible, low-cost option that is readily available to achieve the feat. Additional research is needed to confirm the findings of this trial.
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
Quality Garant
Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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