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January 19, 2023
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Does krill oil influence longevity? Results from a promising pilot study
Krill oil reduces energy metabolism, oxidative stress, and excitotoxicity in a study on roundworms.
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Krill oil (KO) is derived from a crustacean marine species that inhabits the Antarctic waters. This oil consists of triacylglycerols, phospholipids, astaxanthin, and vitamins. Due to structural properties of its phospholipids, its bioavailability has been found to be higher than that of fish oil. When investigated for its potential use, KO demonstrated a variety of biological activities like antioxidation, lifespan prolongation, and reduced inflammation. Preclinical studies have demonstrated the positive effects of KO on lipid, glucose, and energy metabolism. In contrast, polar compounds (PCs) from frying oil were found to induce oxidative stress and metabolic irregularities.
To test the effects of KO, the researchers chose Caenorhabditis elegans, a roundworm, as the model organism due to its short life-cycle and the similarities it shares with mammals when it comes to disease pathways. These reasons along with a well-established metabolomic profile made this organism the ideal test subject to determine the effect.
To measure the effect of KO on the lifespan and locomotion, the investigators divided C. elegans into 4 groups that were given KO, PCs, a mixture of PCs and KO, and Tween 80. The latter was used as the control group and as an emulsifier in other groups. The KO group had the highest locomotion and the longest lifespan, reaching about 23 days. In contrast, the PCs group performed the worst with a median survival of 14 days and decreased locomotion. In the PC + KO group, the presence of KO improved mobility and prolonged the lifespan by about 18%, from a median of 14 days to 16.5 days. As for the control group, the researchers found that it performed better than the PCs group in terms of lifespan and mobility outcomes. The investigators concluded that KO reduces energy metabolism, oxidative stress, and excitotoxicity and restores the damage caused by PCs on longevity and motility of C. elegans.
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Krill oil (KO) is derived from a crustacean marine species that inhabits the Antarctic waters. This oil consists of triacylglycerols, phospholipids, astaxanthin, and vitamins. Due to structural properties of its phospholipids, its bioavailability has been found to be higher than that of fish oil. When investigated for its potential use, KO demonstrated a variety of biological activities like antioxidation, lifespan prolongation, and reduced inflammation. Preclinical studies have demonstrated the positive effects of KO on lipid, glucose, and energy metabolism. In contrast, polar compounds (PCs) from frying oil were found to induce oxidative stress and metabolic irregularities.
To test the effects of KO, the researchers chose Caenorhabditis elegans, a roundworm, as the model organism due to its short life-cycle and the similarities it shares with mammals when it comes to disease pathways. These reasons along with a well-established metabolomic profile made this organism the ideal test subject to determine the effect.
To measure the effect of KO on the lifespan and locomotion, the investigators divided C. elegans into 4 groups that were given KO, PCs, a mixture of PCs and KO, and Tween 80. The latter was used as the control group and as an emulsifier in other groups. The KO group had the highest locomotion and the longest lifespan, reaching about 23 days. In contrast, the PCs group performed the worst with a median survival of 14 days and decreased locomotion. In the PC + KO group, the presence of KO improved mobility and prolonged the lifespan by about 18%, from a median of 14 days to 16.5 days. As for the control group, the researchers found that it performed better than the PCs group in terms of lifespan and mobility outcomes. The investigators concluded that KO reduces energy metabolism, oxidative stress, and excitotoxicity and restores the damage caused by PCs on longevity and motility of C. elegans.
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
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Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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