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DunedinPACE - a new blood test to measure the pace of biological aging
The test is based on an analysis of chemical tags on the DNA contained in white blood cells - DNA methylation marks.
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A new blood test measuring the pace of biological aging was developed by a group of researchers at Columbia University Mailman School of Public Health. The test was named DunedinPACE after the Dunedin Birth Cohort which was used to create it. PACE stands for Pace of Aging Computed from the Epigenome. The test is based on an analysis of chemical tags on the DNA contained in white blood cells, called DNA methylation marks. The high test-retest reliability results of DunedinPACE were published in the e-Life journal.
In the publication led by Daniel Belsky, Ph.D., DunedinPACE is described as a test that measures the speed of aging. DunedinPACE soon might be used as a sensitive tool to detect the effects of interventions slowing aging or processes accelerating the aging. DunedinPACE was proven to be as reliable as the GrimAge clock and more reliable than the other clocks.
Research on DunedinPACE measured changes in nearly 20 biomarkers of organ-system integrity in the Dunedin Study birth cohort (n=1000). Members of the cohort have been enrolled in the study at birth from 1972 to 1973 and have been followed up since. The most recent follow-up was at the time of their 45th birthday. Datapoints have been collected from the members across 20 years at ages 26, 32, 38, and 45 years. Using a single-year birth cohort ensures DunedinPACE is not contaminated by biases that may affect studies that compare older to younger people.
More data have also been obtained from the Understanding Society Study, the Normative Aging Study, the Framingham Heart Study, and the Environmental Risk Longitudinal Twin Study. According to the study, midlife and older adults with faster DunedinPACE were at increased risk of chronic disease incidence, disability, and mortality. DunedinPACE was correlated with the measurement of biological age obtained from blood chemistry, DNA methylation data, and the participants’ subjective perceptions of their health. DunedinPACE also proved a faster Pace of Aging in young adults with a history of childhood adversity, poverty, and victimization.
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A new blood test measuring the pace of biological aging was developed by a group of researchers at Columbia University Mailman School of Public Health. The test was named DunedinPACE after the Dunedin Birth Cohort which was used to create it. PACE stands for Pace of Aging Computed from the Epigenome. The test is based on an analysis of chemical tags on the DNA contained in white blood cells, called DNA methylation marks. The high test-retest reliability results of DunedinPACE were published in the e-Life journal.
In the publication led by Daniel Belsky, Ph.D., DunedinPACE is described as a test that measures the speed of aging. DunedinPACE soon might be used as a sensitive tool to detect the effects of interventions slowing aging or processes accelerating the aging. DunedinPACE was proven to be as reliable as the GrimAge clock and more reliable than the other clocks.
Research on DunedinPACE measured changes in nearly 20 biomarkers of organ-system integrity in the Dunedin Study birth cohort (n=1000). Members of the cohort have been enrolled in the study at birth from 1972 to 1973 and have been followed up since. The most recent follow-up was at the time of their 45th birthday. Datapoints have been collected from the members across 20 years at ages 26, 32, 38, and 45 years. Using a single-year birth cohort ensures DunedinPACE is not contaminated by biases that may affect studies that compare older to younger people.
More data have also been obtained from the Understanding Society Study, the Normative Aging Study, the Framingham Heart Study, and the Environmental Risk Longitudinal Twin Study. According to the study, midlife and older adults with faster DunedinPACE were at increased risk of chronic disease incidence, disability, and mortality. DunedinPACE was correlated with the measurement of biological age obtained from blood chemistry, DNA methylation data, and the participants’ subjective perceptions of their health. DunedinPACE also proved a faster Pace of Aging in young adults with a history of childhood adversity, poverty, and victimization.
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
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Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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