Longevity Conferences 2023
January 19, 2023
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Genome wide association studies (GWAS)
Genome-wide association studies help us identify potential causal regions associated with different diseases and potential genetic explanations for the cause of aging.
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The cost of sequencing DNA just keeps getting cheaper. This has enabled very large datasets of the DNA sequence of many individuals from around the world to be collected. Some of these individuals have specific diseases or characteristics, or maybe they are centenarians. By grouping these datasets into diseases versus non-disease, you can start to look at the DNA sequence and see if there are any sites where this is a mutation or genomic change that is associated with the disease. This is the premise behind genome-wide association studies which we will explain in this video. As we will see, they have been very informative for helping us identify potential causal regions associated with different diseases and of relevance for this video, help us identify potential genetic explanations for the cause of aging. This then enables us to consider questions such as “how much of lifespan is heritable?”
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The cost of sequencing DNA just keeps getting cheaper. This has enabled very large datasets of the DNA sequence of many individuals from around the world to be collected. Some of these individuals have specific diseases or characteristics, or maybe they are centenarians. By grouping these datasets into diseases versus non-disease, you can start to look at the DNA sequence and see if there are any sites where this is a mutation or genomic change that is associated with the disease. This is the premise behind genome-wide association studies which we will explain in this video. As we will see, they have been very informative for helping us identify potential causal regions associated with different diseases and of relevance for this video, help us identify potential genetic explanations for the cause of aging. This then enables us to consider questions such as “how much of lifespan is heritable?”
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
Quality Garant
Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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