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Is high or low IGF1 signalling better for longevity? (VIDEO)
The IGF-1 pathway is involved in response to nutrients and growth factors. We will examine the signalling pathway further, see how it is activated and what processes it regulates.
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Many different signalling pathways within a cell have been linked with aging. But one pathway that appears conserved across many model organisms is the insulin/insulin-like growth factor signalling pathway, otherwise known as the IGF-1 pathway. Primarily this pathway is involved in response to nutrients and growth factors. In this video, we will examine the signalling pathway further, see how it is activated and what processes it regulates. We will then look at the evidence in the literature showing how IGF-1 signalling is implicated in aging and longevity as well as see outcomes of human patients who have genetic diseases in this pathway. Then lastly, we will discuss ways in which the IGF-1 pathway can be intervened.
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Many different signalling pathways within a cell have been linked with aging. But one pathway that appears conserved across many model organisms is the insulin/insulin-like growth factor signalling pathway, otherwise known as the IGF-1 pathway. Primarily this pathway is involved in response to nutrients and growth factors. In this video, we will examine the signalling pathway further, see how it is activated and what processes it regulates. We will then look at the evidence in the literature showing how IGF-1 signalling is implicated in aging and longevity as well as see outcomes of human patients who have genetic diseases in this pathway. Then lastly, we will discuss ways in which the IGF-1 pathway can be intervened.
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
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Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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