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Non-pituitary growth hormone damages colon epithelial cells and promotes DNA damage accumulation
Non-pituitary growth hormone damages colon epithelial cells and promotes DNA damage accumulation
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Accumulation of DNA damage and insufficient DNA repair causes mutation and age-related pathologies. A study showed that aging induces non-pituitary growth hormone (npGH) in organoids of human colon epithelium and fibroblasts. Results are increased p16, senescence, and telomere shortening, that are consistent with age-associated changes. In vivo experiment in mice confirmed the findings. It means that npGH enhances age-associated colon DNA damage accumulation.
Source: cell.com
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Accumulation of DNA damage and insufficient DNA repair causes mutation and age-related pathologies. A study showed that aging induces non-pituitary growth hormone (npGH) in organoids of human colon epithelium and fibroblasts. Results are increased p16, senescence, and telomere shortening, that are consistent with age-associated changes. In vivo experiment in mice confirmed the findings. It means that npGH enhances age-associated colon DNA damage accumulation.
Source: cell.com
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Dr. Ana Baroni MD. Ph.D.
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Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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