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Omega-3 supplementation could improve cognitive function in midlife
Research on older adults has shown that higher Omega-3 intake resulted in larger total brain volumes, better cognitive function, lower risk of Alzheimer's disease, and other substantial benefits.
Diet is a modifiable risk factor that plays a role in brain health. Research on older adults (aged between 67 to 84) has shown that higher omega-3 intake resulted in larger total brain volumes. In addition, omega-3 consumption increased hippocampus and gray matter volumes and decreased amygdala volume over time. Furthermore, older adults who consumed omega-3 were found to have better cognitive function, lower risk of Alzheimer's disease, reduced prevalence of subclinical infarcts, and other substantial benefits.
Population-based studies show beneficial brain outcomes associated with omega-3 use. However, studies utilizing omega-3 as a dietary intervention in people with mild cognitive impairment or Alzheimer's dementia do not present clear data regarding improvements in these conditions. This is possibly attributed to the late utilization of the intervention when substantial neurological damage has occurred.
Limited research has explored the link between omega-3 levels and middle-aged adults' earliest markers of abnormal brain aging. The latter is believed to be the period where neuropathological changes take place. Thus, Satizabal et al. explored the association between red blood cell (RBC) omega-3 concentration and structural brain measures using magnetic resonance imaging (MRI) and cognitive markers of brain aging. The sample consisted of over 2100 dementia- and stroke-free individuals with a mean age of 46 years. Those participants were from the Third-Generation and Omni 2 cohorts of the Framingham Heart Study.
Results revealed that RBC omega-3 levels were associated with larger hippocampal volumes and improved abstract reasoning (using similarities test) at midlife. Further analysis revealed that only moderate omega-3 consumption might be enough to preserve structural and functional brain capacity, suggesting a threshold effect.
The researchers found that higher RBC omega-3 levels relate to larger hippocampal volumes and improved abstract reasoning performance, even in cognitively healthy individuals in their midlife. This suggests an improved cognitive resilience for those individuals. Further research is needed to validate these findings. Nevertheless, this shows the importance of maintaining sufficient omega-3 levels.
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Diet is a modifiable risk factor that plays a role in brain health. Research on older adults (aged between 67 to 84) has shown that higher omega-3 intake resulted in larger total brain volumes. In addition, omega-3 consumption increased hippocampus and gray matter volumes and decreased amygdala volume over time. Furthermore, older adults who consumed omega-3 were found to have better cognitive function, lower risk of Alzheimer's disease, reduced prevalence of subclinical infarcts, and other substantial benefits.
Population-based studies show beneficial brain outcomes associated with omega-3 use. However, studies utilizing omega-3 as a dietary intervention in people with mild cognitive impairment or Alzheimer's dementia do not present clear data regarding improvements in these conditions. This is possibly attributed to the late utilization of the intervention when substantial neurological damage has occurred.
Limited research has explored the link between omega-3 levels and middle-aged adults' earliest markers of abnormal brain aging. The latter is believed to be the period where neuropathological changes take place. Thus, Satizabal et al. explored the association between red blood cell (RBC) omega-3 concentration and structural brain measures using magnetic resonance imaging (MRI) and cognitive markers of brain aging. The sample consisted of over 2100 dementia- and stroke-free individuals with a mean age of 46 years. Those participants were from the Third-Generation and Omni 2 cohorts of the Framingham Heart Study.
Results revealed that RBC omega-3 levels were associated with larger hippocampal volumes and improved abstract reasoning (using similarities test) at midlife. Further analysis revealed that only moderate omega-3 consumption might be enough to preserve structural and functional brain capacity, suggesting a threshold effect.
The researchers found that higher RBC omega-3 levels relate to larger hippocampal volumes and improved abstract reasoning performance, even in cognitively healthy individuals in their midlife. This suggests an improved cognitive resilience for those individuals. Further research is needed to validate these findings. Nevertheless, this shows the importance of maintaining sufficient omega-3 levels.
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
Quality Garant
Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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