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Physical activity in older adults protects brain integrity
The study on cognitively intact older adults aged 65 years revealed that higher levels of physical activity corresponded with higher grey matter volume.
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Physical activity (PA) is one of the cornerstones for preventing age-related decline in cognitive ability. Literature suggests that older adults who engage in PA have better brain integrity and are less likely to develop conditions like dementia and Alzheimer’s disease. This is reflected as increased grey matter (GM) volume, enhanced cerebral glucose metabolism, reduced amyloid burden, and decreased white matter hyperintensities (WMH) (white matter lesions). Preclinical studies on animal models have highlighted that PA promotes neurogenesis, cell survival, and other activities, but this has not been fully elucidated in clinical trials. Felisatti et al. explored whether the link between PA and brain integrity assessed by multimodal neuroimaging, including GM volume, WHM, and others, is mediated by cardiovascular risk factors.
The study included cognitively intact older adults aged 65 years and above. Results revealed that higher PA levels corresponded with higher grey matter volume, and this relationship was described as linear. In addition, cerebral glucose metabolism was improved, and the association was described as linear. Other parameters that improved with PA included insulin levels and body mass index (BMI). After checking the link between cardiovascular factors and neuroimaging measures, the authors found that lower insulin and BMI were associated with higher GM volume. The researchers highlighted that higher PA was not associated with amyloid burden, WMH, or WM structural integrity. In addition, it did not influence cholesterol levels or blood pressure.
The authors concluded that practicing physical activity by older adults is associated with improved GM and cardiovascular benefits mediated by lower insulin levels and BMI, which contributes to brain integrity. This study could pave the way to a better understanding of the influence of PA on brain health, which could guide the development of preventive cognitive-deterioration deaccelerating strategies.
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Physical activity (PA) is one of the cornerstones for preventing age-related decline in cognitive ability. Literature suggests that older adults who engage in PA have better brain integrity and are less likely to develop conditions like dementia and Alzheimer’s disease. This is reflected as increased grey matter (GM) volume, enhanced cerebral glucose metabolism, reduced amyloid burden, and decreased white matter hyperintensities (WMH) (white matter lesions). Preclinical studies on animal models have highlighted that PA promotes neurogenesis, cell survival, and other activities, but this has not been fully elucidated in clinical trials. Felisatti et al. explored whether the link between PA and brain integrity assessed by multimodal neuroimaging, including GM volume, WHM, and others, is mediated by cardiovascular risk factors.
The study included cognitively intact older adults aged 65 years and above. Results revealed that higher PA levels corresponded with higher grey matter volume, and this relationship was described as linear. In addition, cerebral glucose metabolism was improved, and the association was described as linear. Other parameters that improved with PA included insulin levels and body mass index (BMI). After checking the link between cardiovascular factors and neuroimaging measures, the authors found that lower insulin and BMI were associated with higher GM volume. The researchers highlighted that higher PA was not associated with amyloid burden, WMH, or WM structural integrity. In addition, it did not influence cholesterol levels or blood pressure.
The authors concluded that practicing physical activity by older adults is associated with improved GM and cardiovascular benefits mediated by lower insulin levels and BMI, which contributes to brain integrity. This study could pave the way to a better understanding of the influence of PA on brain health, which could guide the development of preventive cognitive-deterioration deaccelerating strategies.
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Dr. Ana Baroni MD. Ph.D.
Scientific & Medical Advisor
Quality Garant
Ana has over 20 years of consultancy experience in longevity, regenerative and precision medicine. She has a multifaceted understanding of genomics, molecular biology, clinical biochemistry, nutrition, aging markers, hormones and physical training. This background allows her to bridge the gap between longevity basic sciences and evidence-based real interventions, putting them into the clinic, to enhance the healthy aging of people. She is co-founder of Origen.life, and Longevityzone. Board member at Breath of Health, BioOx and American Board of Clinical Nutrition. She is Director of International Medical Education of the American College of Integrative Medicine, Professor in IL3 Master of Longevity at Barcelona University and Professor of Nutrigenomics in Nutrition Grade in UNIR University.
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